Neuromedin-K receptor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-12Neuromedin-K receptor shows approved-linked disease relevance led by Hot flashes. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P29371. Start with Hot flashes, then reuse UniProt P29371 as the stable protein anchor across project notes and exports.
Start with Hot flashes, then reuse UniProt P29371 as the stable protein anchor across project notes and exports.
Neuromedin-K receptor shows approved-linked disease relevance led by Hot flashes. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with Hot flashes because it currently carries approved-linked support. Linked drugs include ELINZANETANT, FEZOLINETANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNeuromedin-K receptor
Review this target as Neuromedin-K receptor, mapped to UniProt P29371. Sequence length is 465 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neuromedin-K receptor as ChEMBL target CHEMBL4429, mapped to UniProt P29371. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Neuromedin-K receptor is the right protein anchor across sources, using UniProt P29371 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Hot flashes is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Neuromedin-K receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P29371 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neuromedin-K receptor |
| UniProt Accession | P29371 |
| Component Type | Protein |
| Sequence Length | 465 aa |
Neuromedin-K receptor
Review this target as Neuromedin-K receptor, mapped to UniProt P29371. Sequence length is 465 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Neuromedin-K receptor shows approved-linked disease relevance led by Hot flashes. 5 more disease programs remain visible in the same review block.
Start review with Hot flashes because it currently carries approved-linked support. Linked drugs include ELINZANETANT, FEZOLINETANT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3736177 | 10.96 | EC50 | 0.011 | Preclinical |
| CHEMBL2347491 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL3735159 | 10.92 | EC50 | 0.012 | Preclinical |
| CHEMBL583102 | 10.89 | EC50 | 0.013 | Preclinical |
| CHEMBL3735427 | 10.89 | EC50 | 0.013 | Preclinical |
| CHEMBL3736361 | 10.85 | EC50 | 0.014 | Preclinical |
| CHEMBL2347513 | 10.77 | EC50 | 0.017 | Preclinical |
| CHEMBL3736299 | 10.77 | EC50 | 0.017 | Preclinical |
| CHEMBL3735858 | 10.77 | EC50 | 0.017 | Preclinical |
| CHEMBL3736512 | 10.74 | EC50 | 0.018 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 98 | 102 | 7.3 |
| cell-based format | 91 | 705 | 7.5 |
| assay format | 21 | 234 | 7.2 |
| cell membrane format | 2 | 31 | 6.7 |
| tissue-based format | 1 | 1 | 5.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 40 | 252 | 7.7 |
| assay format | 3 | 0 | — |
| organism-based format | 3 | 0 | — |
| cell membrane format | 1 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 2 | 7.8 |