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Compound Detail

CHEMBL3735427

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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(N)=O)C(N)=O

Basic Information

ChEMBL ID CHEMBL3735427
Phase Preclinical
Structure Type MOL
InChI Key TYNBXRQKWGGDOB-ZIUUJSQJSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

784.9
MW (Da)
-0.33
ALogP
9
HBA
8
HBD
272.2
PSA (Ų)
0.07
QED
2
Ro5 Violations
23
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C37H52N8O9S
MW 784.94
Aromatic Rings 2
Heavy Atoms 55
NP-Likeness -0.24

Activity Summary

EC50 1 meas. best 10.89
IC50 1 meas. best 7.41

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuromedin-K receptor
CHEMBL4429
EC50 10.89 10.89 0.0 1
Neuromedin-K receptor
CHEMBL4429
IC50 7.41 7.41 39.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00514G Neuromedin-K receptor 2
- 10.1039/C4MD00514G Substance-P receptor 1
- 10.1039/C4MD00514G Substance-K receptor 1

Data from ChEMBL 36 via Core Engine