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Compound Detail

CHEMBL3736361

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CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CCC(=O)O)NC(=O)C(=O)O)C(N)=O

Basic Information

ChEMBL ID CHEMBL3736361
Phase Preclinical
Structure Type MOL
InChI Key GRMREWPIXQSXKU-RULDIGERSA-N
2
Targets
5
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

828.0
MW (Da)
-0.41
ALogP
10
HBA
8
HBD
283.5
PSA (Ų)
0.06
QED
2
Ro5 Violations
24
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C39H53N7O11S
MW 827.96
Aromatic Rings 2
Heavy Atoms 58
NP-Likeness -0.12

Activity Summary

EC50 4 meas. best 10.85
IC50 1 meas. best 9.29

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Neuromedin-K receptor
CHEMBL4429
EC50 10.85 10.85 0.0 1
Unchecked
CHEMBL612545
EC50 9.82 9.82 0.2 1
Neuromedin-K receptor
CHEMBL4429
IC50 9.29 9.29 0.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1039/C4MD00514G Neuromedin-K receptor 4
- 10.1039/C4MD00514G Unchecked 4
- 10.1039/C4MD00514G Serum 2
- 10.1039/C4MD00514G Substance-P receptor 1
- 10.1039/C4MD00514G Substance-K receptor 1
- 10.1039/C4MD00514G ADMET 1
- 10.1039/C4MD00514G Neprilysin 1

Data from ChEMBL 36 via Core Engine