Assay Detail
Binding
CHEMBL1763155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human NK3 receptor by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.39 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 8.72 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 8.13 |
| CHEMBL1760206 | — | — | 1 | 6.43 |
| CHEMBL1760205 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL10188 | TALNETANT | Ki | = | 7.4 | nM | 8.13 |
| CHEMBL1760206 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL1760205 | — | Ki | = | 540.0 | nM | 6.27 |