Assay Detail
Binding
CHEMBL1763156
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Binding affinity to human NK2 receptor by radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of 3-aryl-5-acylpiperazinyl-pyrazoles as antagonists to the NK3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.60 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | 2.0 | 1 | 7.07 |
| CHEMBL10188 | TALNETANT | 2.0 | 1 | 5.43 |
| CHEMBL1760205 | — | — | 1 | 5.00 |
| CHEMBL1760206 | — | — | 1 | 4.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL346178 | OSANETANT | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL10188 | TALNETANT | Ki | = | 3700.0 | nM | 5.43 |
| CHEMBL1760205 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1760206 | — | Ki | = | 13000.0 | nM | 4.89 |