Assay Detail
Binding
CHEMBL1763172
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of iNOS in intact human DLD1 cells assessed as nitric oxide production
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | DLD-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.87 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762474 | — | — | 1 | 6.70 |
| CHEMBL1762480 | — | — | 1 | 6.22 |
| CHEMBL1762472 | — | — | 1 | 6.16 |
| CHEMBL1762479 | — | — | 1 | 6.16 |
| CHEMBL1762481 | — | — | 1 | 6.14 |
| CHEMBL1762473 | — | — | 1 | 6.05 |
| CHEMBL447183 | — | — | 1 | 6.00 |
| CHEMBL1762475 | — | — | 1 | 5.57 |
| CHEMBL1762478 | — | — | 1 | 5.44 |
| CHEMBL1762471 | — | — | 1 | 5.06 |
| CHEMBL1762476 | — | — | 1 | 5.02 |
| CHEMBL1762470 | — | — | 1 | - |
| CHEMBL1762477 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762474 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1762480 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1762472 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1762479 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1762481 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1762473 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL447183 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1762475 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL1762478 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1762471 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL1762476 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL1762470 | — | IC50 | - | — | - | |
| CHEMBL1762477 | — | IC50 | - | — | - |