Assay Detail
Binding
CHEMBL1763333
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Inhibition of c-Jun
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.57 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761563 | — | — | 1 | 7.70 |
| CHEMBL1761583 | — | — | 1 | 7.40 |
| CHEMBL1761582 | — | — | 1 | 7.40 |
| CHEMBL1761561 | — | — | 1 | 7.40 |
| CHEMBL1761584 | — | — | 1 | 7.30 |
| CHEMBL1761577 | — | — | 1 | 7.00 |
| CHEMBL1761555 | — | — | 1 | 6.92 |
| CHEMBL1761581 | — | — | 1 | 6.89 |
| CHEMBL1761579 | — | — | 1 | 6.80 |
| CHEMBL1761569 | — | — | 1 | 6.70 |
| CHEMBL1761565 | — | — | 1 | 6.60 |
| CHEMBL1761562 | — | — | 1 | 6.54 |
| CHEMBL1761554 | — | — | 1 | 6.51 |
| CHEMBL1761564 | — | — | 1 | 6.48 |
| CHEMBL1761568 | — | — | 1 | 6.30 |
| CHEMBL1761578 | — | — | 1 | 6.21 |
| CHEMBL1761572 | — | — | 1 | 6.20 |
| CHEMBL1761575 | — | — | 1 | 6.03 |
| CHEMBL1761567 | — | — | 1 | 5.85 |
| CHEMBL1761576 | — | — | 1 | 5.52 |
| CHEMBL1761566 | — | — | 1 | 5.52 |
| CHEMBL1761570 | — | — | 1 | 5.29 |
| CHEMBL1761574 | — | — | 1 | - |
| CHEMBL1761573 | — | — | 1 | - |
| CHEMBL1761571 | — | — | 1 | - |
| CHEMBL1761558 | — | — | 1 | - |
| CHEMBL1761580 | — | — | 1 | - |
| CHEMBL1761559 | — | — | 1 | - |
| CHEMBL1761557 | — | — | 1 | - |
| CHEMBL1761556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761563 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1761583 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761582 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761561 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1761584 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1761577 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1761555 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1761581 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1761579 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1761569 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1761565 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL1761562 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1761554 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL1761564 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL1761568 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1761578 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL1761572 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1761575 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1761567 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1761576 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1761566 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1761570 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1761574 | — | IC50 | - | — | - | |
| CHEMBL1761573 | — | IC50 | - | — | - | |
| CHEMBL1761571 | — | IC50 | - | — | - | |
| CHEMBL1761558 | — | IC50 | - | — | - | |
| CHEMBL1761580 | — | IC50 | - | — | - | |
| CHEMBL1761559 | — | IC50 | - | — | - | |
| CHEMBL1761557 | — | IC50 | - | — | - | |
| CHEMBL1761556 | — | IC50 | - | — | - | |
| CHEMBL1761560 | — | IC50 | - | — | - |