Assay Detail
Functional
CHEMBL1763373
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Antiinflammatory activity in CD-1 mouse Macrophage assessed as inhibition of IFN-gamma induced NO production after 48 hrs by Griess reaction
23
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | Macrophage |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.76 | 10.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224752 | — | — | 1 | 10.25 |
| CHEMBL1762621 | BARDOXOLONE METHYL | 3.0 | 1 | 9.70 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 2 | 9.30 |
| CHEMBL1762616 | — | — | 1 | 8.89 |
| CHEMBL356121 | — | — | 2 | 8.68 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 8.00 |
| CHEMBL1762619 | — | — | 2 | 7.72 |
| CHEMBL1762620 | — | — | 1 | 7.58 |
| CHEMBL342544 | — | — | 1 | 7.28 |
| CHEMBL1762614 | — | — | 1 | 7.24 |
| CHEMBL142344 | — | — | 1 | 7.21 |
| CHEMBL415458 | — | — | 2 | 7.21 |
| CHEMBL146553 | — | — | 1 | 7.12 |
| CHEMBL343629 | — | — | 1 | 7.04 |
| CHEMBL145011 | — | — | 1 | 6.51 |
| CHEMBL144916 | — | — | 1 | 6.32 |
| CHEMBL343446 | — | — | 1 | 5.80 |
| CHEMBL1762617 | — | — | 1 | - |
| CHEMBL1762613 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224752 | — | IC50 | = | 0.056 | nM | 10.25 |
| CHEMBL1762621 | BARDOXOLONE METHYL | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL1762616 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL356121 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL356121 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1762619 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1762619 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1762620 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL342544 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL1762614 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL415458 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL142344 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL415458 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL146553 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL343629 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL145011 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL144916 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL343446 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1762613 | — | IC50 | > | 600.0 | nM | - |
| CHEMBL1762617 | — | IC50 | > | 60.0 | nM | - |