Assay Detail
Functional
CHEMBL1763374
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Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFN-gamma induced NO production after 24 hrs by Griess reaction
43
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Tricyclic compounds containing nonenolizable cyano enones. A novel class of highly potent anti-inflammatory and cytoprotective agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.54 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL224752 | — | — | 2 | 9.00 |
| CHEMBL1762757 | — | — | 1 | 9.00 |
| CHEMBL1720855 | — | — | 1 | 9.00 |
| CHEMBL1762758 | — | — | 1 | 8.70 |
| CHEMBL222861 | — | — | 2 | 8.52 |
| CHEMBL1762609 | — | — | 1 | 8.52 |
| CHEMBL376599 | — | — | 1 | 8.40 |
| CHEMBL221714 | — | — | 1 | 8.30 |
| CHEMBL223760 | — | — | 1 | 8.00 |
| CHEMBL225333 | — | — | 1 | 8.00 |
| CHEMBL1762761 | — | — | 1 | 8.00 |
| CHEMBL1093059 | BARDOXOLONE | 2.0 | 1 | 7.77 |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | 7.70 |
| CHEMBL1762762 | — | — | 1 | 7.70 |
| CHEMBL1760027 | — | — | 1 | 7.70 |
| CHEMBL222528 | — | — | 1 | 7.70 |
| CHEMBL356121 | — | — | 1 | 7.64 |
| CHEMBL1762759 | — | — | 1 | 7.46 |
| CHEMBL1762751 | — | — | 1 | 7.40 |
| CHEMBL1762763 | — | — | 1 | 7.30 |
| CHEMBL1762619 | — | — | 1 | 7.24 |
| CHEMBL389621 | HYDROCORTISONE | 4.0 | 1 | 7.21 |
| CHEMBL1762612 | — | — | 1 | 7.19 |
| CHEMBL1762615 | — | — | 1 | 7.19 |
| CHEMBL1762611 | — | — | 1 | 7.10 |
| CHEMBL1762754 | — | — | 1 | 7.10 |
| CHEMBL1762610 | — | — | 1 | 7.08 |
| CHEMBL1762749 | — | — | 1 | 7.08 |
| CHEMBL1762755 | — | — | 1 | 7.08 |
| CHEMBL1762618 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL224752 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1720855 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1762757 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1762758 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1762609 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL224752 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL222861 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL222861 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL376599 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL221714 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1762761 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL225333 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL223760 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1093059 | BARDOXOLONE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL222528 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1760027 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1762762 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL384467 | DEXAMETHASONE | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL356121 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1762759 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1762751 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1762763 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1762619 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL389621 | HYDROCORTISONE | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL1762612 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1762615 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL1762611 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1762754 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1762610 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1762749 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1762755 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1762618 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL415458 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL1762608 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1762756 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL1762623 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL1762753 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL1762622 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL1762606 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL1762752 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL1762760 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1762607 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1762750 | — | IC50 | > | 10000.0 | nM | - |