Assay Detail
Binding
CHEMBL1763403
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Competitive inhibition of recombinant TAK1-TAB1 assessed as [33P]gamma-ATP incorporation into substrate histone H1 peptide by filter plate assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Oxindole derivatives as inhibitors of TAK1 kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.17 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1077979 | — | — | 1 | 8.10 |
| CHEMBL1761718 | — | — | 1 | 8.05 |
| CHEMBL1761588 | — | — | 1 | 7.68 |
| CHEMBL1761586 | — | — | 1 | 7.38 |
| CHEMBL1761585 | — | — | 1 | 7.34 |
| CHEMBL1761587 | — | — | 1 | 7.00 |
| CHEMBL1761749 | — | — | 1 | 6.25 |
| CHEMBL1761742 | — | — | 1 | 6.20 |
| CHEMBL1761747 | — | — | 1 | 5.77 |
| CHEMBL1761719 | — | — | 1 | 5.52 |
| CHEMBL1761750 | — | — | 1 | 5.39 |
| CHEMBL1761739 | — | — | 1 | 5.24 |
| CHEMBL1761737 | — | — | 1 | 5.09 |
| CHEMBL1761738 | — | — | 1 | 4.60 |
| CHEMBL1761740 | — | — | 1 | 4.60 |
| CHEMBL1761736 | — | — | 1 | 4.52 |
| CHEMBL1761743 | — | — | 1 | - |
| CHEMBL1761744 | — | — | 1 | - |
| CHEMBL1761746 | — | — | 1 | - |
| CHEMBL1761735 | — | — | 1 | - |
| CHEMBL1761730 | — | — | 1 | - |
| CHEMBL1761729 | — | — | 1 | - |
| CHEMBL190880 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1077979 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1761718 | — | IC50 | = | 8.9 | nM | 8.05 |
| CHEMBL1761588 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1761586 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL1761585 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL1761587 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL1761749 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL1761742 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1761747 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL1761719 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1761750 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL1761739 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL1761737 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL1761738 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1761740 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1761736 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL1761743 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1761744 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1761746 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1761735 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL1761730 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL1761729 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL190880 | — | IC50 | > | 5000.0 | nM | - |