Assay Detail
Binding
CHEMBL1763498
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Inhibition of human erythrocyte recombinant AChE by modified Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 6.20 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 9.15 |
| CHEMBL225577 | — | — | 1 | 9.00 |
| CHEMBL105257 | — | — | 1 | 8.00 |
| CHEMBL104387 | — | — | 1 | 7.70 |
| CHEMBL464538 | — | — | 1 | 7.52 |
| CHEMBL1761995 | — | — | 1 | 7.10 |
| CHEMBL105017 | — | — | 1 | 7.10 |
| CHEMBL1761994 | — | — | 1 | 7.05 |
| CHEMBL1762003 | — | — | 1 | 6.10 |
| CHEMBL1761999 | — | — | 1 | 5.70 |
| CHEMBL1761993 | — | — | 1 | 5.40 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 5.30 |
| CHEMBL1761998 | — | — | 1 | 5.22 |
| CHEMBL1761991 | — | — | 1 | 5.05 |
| CHEMBL601410 | — | — | 1 | 4.60 |
| CHEMBL1762000 | — | — | 1 | 4.46 |
| CHEMBL1761997 | — | — | 1 | 4.46 |
| CHEMBL1761992 | — | — | 1 | 4.42 |
| CHEMBL1762001 | — | — | 1 | 4.40 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | 4.0 | 1 | - |
| CHEMBL1761996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL225577 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL105257 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL104387 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL464538 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1761995 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL105017 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL1761994 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL1762003 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1761999 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1761993 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1761998 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1761991 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL601410 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1762000 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1761997 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL1761992 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL1762001 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | IC50 | = | 1020000.0 | nM | - |
| CHEMBL1761996 | — | IC50 | = | 418000.0 | nM | - |