Assay Detail
Binding
CHEMBL1763500
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Inhibition of human plasmatic BChE by modified Ellman's method
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.63 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL225577 | — | — | 1 | 7.00 |
| CHEMBL1762003 | — | — | 1 | 6.70 |
| CHEMBL1761994 | — | — | 1 | 6.40 |
| CHEMBL104387 | — | — | 1 | 6.40 |
| CHEMBL105257 | — | — | 1 | 6.30 |
| CHEMBL105017 | — | — | 1 | 6.22 |
| CHEMBL1761995 | — | — | 1 | 6.16 |
| CHEMBL1761999 | — | — | 1 | 6.10 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | 4.0 | 1 | 5.80 |
| CHEMBL601410 | — | — | 1 | 5.30 |
| CHEMBL1762000 | — | — | 1 | 5.22 |
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 5.16 |
| CHEMBL1761991 | — | — | 1 | 4.89 |
| CHEMBL1762001 | — | — | 1 | 4.70 |
| CHEMBL1761992 | — | — | 1 | 4.50 |
| CHEMBL1761993 | — | — | 1 | 4.47 |
| CHEMBL1761997 | — | — | 1 | 4.32 |
| CHEMBL1761998 | — | — | 1 | - |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | - |
| CHEMBL1761996 | — | — | 1 | - |
| CHEMBL464538 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL225577 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL1762003 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1761994 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL104387 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL105257 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL105017 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL1761995 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1761999 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL601410 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1762000 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1761991 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1762001 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1761992 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1761993 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL1761997 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL1761998 | — | IC50 | = | 308000.0 | nM | - |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | IC50 | = | 1370000.0 | nM | - |
| CHEMBL1761996 | — | IC50 | = | 871000.0 | nM | - |
| CHEMBL464538 | — | IC50 | = | 354000.0 | nM | - |