Assay Detail
Binding
CHEMBL1763502
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human erythrocytes recombinant AChE assessed as dissociation constant for enzyme-inhibitor complex
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.67 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | — | 1 | 8.30 |
| CHEMBL464538 | — | — | 1 | 8.00 |
| CHEMBL225577 | — | — | 1 | 7.40 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | 4.0 | 1 | 6.10 |
| CHEMBL1762003 | — | — | 1 | 5.64 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | 4.0 | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1669479 | AMBENONIUM DICHLORIDE | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL464538 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL225577 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL1128 | EDROPHONIUM CHLORIDE | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1762003 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL1200970 | ETHOPROPAZINE HYDROCHLORIDE | Ki | = | 25000.0 | nM | 4.60 |