Assay Detail
Binding
CHEMBL1763554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human EGFR-mediated poly(Glu4Tyr) phosphorylation after 1 hr
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.95 | 7.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 7.20 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.16 |
| CHEMBL301018 | — | — | 1 | 6.42 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 6.10 |
| CHEMBL1277620 | — | — | 1 | 5.24 |
| CHEMBL1278149 | — | — | 1 | 5.23 |
| CHEMBL1761929 | — | — | 1 | 5.16 |
| CHEMBL98798 | — | — | 1 | 5.12 |
| CHEMBL1761937 | — | — | 1 | - |
| CHEMBL1278235 | — | — | 1 | - |
| CHEMBL1761936 | — | — | 1 | - |
| CHEMBL1277254 | — | — | 1 | - |
| CHEMBL1276893 | — | — | 1 | - |
| CHEMBL1278057 | — | — | 1 | - |
| CHEMBL1276892 | — | — | 1 | - |
| CHEMBL179603 | — | — | 1 | - |
| CHEMBL1761935 | — | — | 1 | - |
| CHEMBL1761934 | — | — | 1 | - |
| CHEMBL1277162 | — | — | 1 | - |
| CHEMBL1761938 | — | — | 1 | - |
| CHEMBL1761939 | — | — | 1 | - |
| CHEMBL1761940 | — | — | 1 | - |
| CHEMBL1761941 | — | — | 1 | - |
| CHEMBL1761942 | — | — | 1 | - |
| CHEMBL1761943 | — | — | 1 | - |
| CHEMBL205089 | — | — | 1 | - |
| CHEMBL1761944 | — | — | 1 | - |
| CHEMBL1761945 | — | — | 1 | - |
| CHEMBL447230 | — | — | 1 | - |
| CHEMBL1277253 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL939 | GEFITINIB | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL301018 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1277620 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1278149 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1761929 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL98798 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL1278057 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278148 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276892 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL179603 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761935 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761934 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1277162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278235 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761932 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761931 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761930 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1278056 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761928 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761927 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1276893 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1277254 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761937 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761938 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761939 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761940 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761941 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761942 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761943 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL205089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761944 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1761945 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL447230 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1277253 | — | IC50 | > | 10000.0 | nM | - |