Assay Detail
Functional
CHEMBL1763559
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Antiproliferative activity against human EAhy926 cells at 10 uM after 72 hrs by MTS assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EA.hy 926 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.24 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL447230 | — | — | 1 | 5.40 |
| CHEMBL301018 | — | — | 1 | 5.35 |
| CHEMBL1761940 | — | — | 1 | 5.30 |
| CHEMBL1761938 | — | — | 1 | 5.29 |
| CHEMBL24828 | VANDETANIB | 4.0 | 1 | 5.29 |
| CHEMBL1761944 | — | — | 1 | 5.28 |
| CHEMBL1278235 | — | — | 1 | 5.17 |
| CHEMBL29197 | — | — | 1 | 5.15 |
| CHEMBL1761933 | — | — | 1 | 5.10 |
| CHEMBL1761939 | — | — | 1 | 5.05 |
| CHEMBL1278148 | — | — | 1 | - |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL447230 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL301018 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1761940 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1761938 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL24828 | VANDETANIB | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1761944 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1278235 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL29197 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL1761933 | — | IC50 | = | 8010.0 | nM | 5.10 |
| CHEMBL1761939 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1278148 | — | IC50 | - | — | - | |
| CHEMBL939 | GEFITINIB | IC50 | - | — | - |