Assay Detail
Binding
CHEMBL1763563
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Inhibition of PI3Kbeta
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.03 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762790 | — | — | 1 | 9.70 |
| CHEMBL1762788 | — | — | 1 | 8.05 |
| CHEMBL1760154 | — | — | 1 | 7.77 |
| CHEMBL1615182 | — | — | 1 | 6.42 |
| CHEMBL1760155 | — | — | 1 | 6.39 |
| CHEMBL1760162 | — | — | 1 | 6.38 |
| CHEMBL1760158 | — | — | 1 | 6.20 |
| CHEMBL1615183 | — | — | 1 | 6.06 |
| CHEMBL1760172 | — | — | 1 | 6.00 |
| CHEMBL1760163 | — | — | 1 | 6.00 |
| CHEMBL1760157 | — | — | 1 | 6.00 |
| CHEMBL1762789 | — | — | 1 | 6.00 |
| CHEMBL1760153 | — | — | 1 | 5.99 |
| CHEMBL1760156 | — | — | 1 | 5.85 |
| CHEMBL1760165 | — | — | 1 | 5.75 |
| CHEMBL1760167 | — | — | 1 | 5.62 |
| CHEMBL1760161 | — | — | 1 | 5.51 |
| CHEMBL1760171 | — | — | 1 | 5.43 |
| CHEMBL1760168 | — | — | 1 | 5.35 |
| CHEMBL1760164 | — | — | 1 | 5.16 |
| CHEMBL1760169 | — | — | 1 | 5.07 |
| CHEMBL1760170 | — | — | 1 | 4.81 |
| CHEMBL1760160 | — | — | 1 | 4.65 |
| CHEMBL1760159 | — | — | 1 | 4.54 |
| CHEMBL1760166 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762790 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL1762788 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1760154 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1615182 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL1760155 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1760162 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1760158 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1615183 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL1760172 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1760163 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1760157 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1762789 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1760153 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1760156 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1760165 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL1760167 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1760161 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1760171 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL1760168 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL1760164 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1760169 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL1760170 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL1760160 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1760159 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL1760166 | — | IC50 | - | — | - |