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Assay Detail

CHEMBL1763569

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of CK1delta at 1 uM relative to control
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Casein kinase I isoform delta (CHEMBL2828)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of triazine-benzimidazoles as selective inhibitors of mTOR.
Peterson EA, Andrews PS, Be X, Boezio AA, Bush TL, Cheng AC, Coats JR, Colletti AE, Copeland KW, DuPont M, Graceffa R, Grubinska B, Harmange JC, Kim JL, Mullady EL, Olivieri P, Schenkel LB, Stanton MK, Teffera Y, Whittington DA, Cai T, La DS.
Bioorg Med Chem Lett (2011) 21 : 2064 -2070
PubMed 21376583 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 4.40 4.40
Inhibition 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1615182 1 4.40
CHEMBL1762782 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1615182 IC50 = 40000.0 nM 4.40
CHEMBL1762782 Inhibition = 90.0 % -