Assay Detail
Binding
CHEMBL1764206
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Inhibition of IKK-alpha
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHEMBL3476) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3,5-Disubstituted-indole-7-carboxamides: the discovery of a novel series of potent, selective inhibitors of IKK-β.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.21 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761510 | — | — | 1 | 5.80 |
| CHEMBL1761514 | — | — | 1 | 5.70 |
| CHEMBL1761512 | — | — | 1 | 5.70 |
| CHEMBL1761513 | — | — | 1 | 5.50 |
| CHEMBL1761501 | — | — | 1 | 5.40 |
| CHEMBL1761509 | — | — | 1 | 5.40 |
| CHEMBL1761503 | — | — | 1 | 5.30 |
| CHEMBL1761504 | — | — | 1 | 5.20 |
| CHEMBL1761515 | — | — | 1 | 5.10 |
| CHEMBL1761500 | — | — | 1 | 5.00 |
| CHEMBL1761511 | — | — | 1 | 5.00 |
| CHEMBL1761499 | — | — | 1 | 5.00 |
| CHEMBL1761508 | — | — | 1 | 4.90 |
| CHEMBL1964241 | — | — | 1 | 4.80 |
| CHEMBL1761506 | — | — | 1 | 4.80 |
| CHEMBL1761505 | — | — | 1 | 4.80 |
| CHEMBL1761502 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761510 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1761514 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1761512 | — | IC50 | = | 1995.26 | nM | 5.70 |
| CHEMBL1761513 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL1761501 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1761509 | — | IC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL1761503 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL1761504 | — | IC50 | = | 6309.57 | nM | 5.20 |
| CHEMBL1761515 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL1761500 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1761511 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1761499 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1761508 | — | IC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL1964241 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1761506 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1761505 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL1761502 | — | IC50 | > | 15848.93 | nM | - |