Assay Detail
Functional
CHEMBL1764263
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against 0.05 MOI Human immunodeficiency virus 1 NL4.3 infected in human CEM cells expressing green fluorescent protein assessed as p24 antigen production measured 7 days post infection by ELISA
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis of 9-substituted derivatives of berberine as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 19 | 6.04 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12089 | BERBERINE CHLORIDE | 1.0 | 1 | 6.89 |
| CHEMBL1761186 | — | — | 1 | 6.02 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 5.98 |
| CHEMBL1761184 | — | — | 1 | 5.74 |
| CHEMBL1223099 | BERBERRUBINE CHLORIDE | — | 1 | 5.55 |
| CHEMBL1761192 | — | — | 1 | - |
| CHEMBL1761191 | — | — | 1 | - |
| CHEMBL1761190 | — | — | 1 | - |
| CHEMBL1761189 | — | — | 1 | - |
| CHEMBL1761188 | — | — | 1 | - |
| CHEMBL1761187 | — | — | 1 | - |
| CHEMBL1223325 | — | — | 1 | - |
| CHEMBL1761185 | — | — | 1 | - |
| CHEMBL1761178 | — | — | 1 | - |
| CHEMBL1761183 | — | — | 1 | - |
| CHEMBL1761182 | — | — | 1 | - |
| CHEMBL1761181 | — | — | 1 | - |
| CHEMBL1761180 | — | — | 1 | - |
| CHEMBL1761179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12089 | BERBERINE CHLORIDE | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL1761186 | — | EC50 | = | 950.0 | nM | 6.02 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL1761184 | — | EC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL1223099 | BERBERRUBINE CHLORIDE | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1761192 | — | EC50 | - | — | - | |
| CHEMBL1761191 | — | EC50 | - | — | - | |
| CHEMBL1761190 | — | EC50 | - | — | - | |
| CHEMBL1761189 | — | EC50 | - | — | - | |
| CHEMBL1761188 | — | EC50 | - | — | - | |
| CHEMBL1761187 | — | EC50 | - | — | - | |
| CHEMBL1223325 | — | EC50 | - | — | - | |
| CHEMBL1761185 | — | EC50 | - | — | - | |
| CHEMBL1761178 | — | EC50 | - | — | - | |
| CHEMBL1761183 | — | EC50 | - | — | - | |
| CHEMBL1761182 | — | EC50 | - | — | - | |
| CHEMBL1761181 | — | EC50 | - | — | - | |
| CHEMBL1761180 | — | EC50 | - | — | - | |
| CHEMBL1761179 | — | EC50 | - | — | - |