Assay Detail
Binding
CHEMBL1764347
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Inhibition of mushroom tyrosinase after 25 mins by spectrophotometry
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationships of phenylpropanoid amides of serotonin on tyrosinase inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 4.79 | 5.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760549 | N-ISOFERULOYL SEROTONIN | — | 1 | 5.27 |
| CHEMBL564482 | N-FERULOYL SEROTONIN | — | 1 | 5.10 |
| CHEMBL1760547 | N-P-COUMAROYL SEROTONIN | — | 1 | 5.06 |
| CHEMBL1760548 | N-P-METHOXY CINNAMOYL SEROTONIN | — | 1 | 4.62 |
| CHEMBL1760546 | N-CINNAMOYL SEROTONIN | — | 1 | 4.39 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.29 |
| CHEMBL559089 | N-CAFFEOYLSEROTONIN | — | 1 | - |
| CHEMBL1760550 | N-3,4-DIMETHOXY CINNAMOYL SEROTONIN | — | 1 | - |
| CHEMBL1760551 | N-SINAPOYL SEROTONIN | — | 1 | - |
| CHEMBL1760552 | BUFOBUTANOIC ACID | — | 1 | - |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | - |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL66879 | COUMARIC ACID | — | 1 | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | — | 1 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
| CHEMBL32749 | FERULATE | -1.0 | 1 | - |
| CHEMBL233295 | ISOFERULIC ACID | — | 1 | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | — | 1 | - |
| CHEMBL109341 | SINAPINATE | — | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760549 | N-ISOFERULOYL SEROTONIN | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL564482 | N-FERULOYL SEROTONIN | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1760547 | N-P-COUMAROYL SEROTONIN | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1760548 | N-P-METHOXY CINNAMOYL SEROTONIN | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL1760546 | N-CINNAMOYL SEROTONIN | IC50 | = | 40400.0 | nM | 4.39 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 51400.0 | nM | 4.29 |
| CHEMBL559089 | N-CAFFEOYLSEROTONIN | IC50 | = | 278100.0 | nM | - |
| CHEMBL1760550 | N-3,4-DIMETHOXY CINNAMOYL SEROTONIN | IC50 | = | 321800.0 | nM | - |
| CHEMBL1760551 | N-SINAPOYL SEROTONIN | IC50 | > | 350000.0 | nM | - |
| CHEMBL1760552 | BUFOBUTANOIC ACID | IC50 | > | 350000.0 | nM | - |
| CHEMBL39 | SEROTONIN | IC50 | > | 350000.0 | nM | - |
| CHEMBL27246 | CINNAMIC ACID | IC50 | > | 350000.0 | nM | - |
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 121300.0 | nM | - |
| CHEMBL95770 | 4-METHOXYCINNAMIC ACID | IC50 | > | 350000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | IC50 | > | 350000.0 | nM | - |
| CHEMBL32749 | FERULATE | IC50 | > | 350000.0 | nM | - |
| CHEMBL233295 | ISOFERULIC ACID | IC50 | = | 115200.0 | nM | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | IC50 | > | 350000.0 | nM | - |
| CHEMBL109341 | SINAPINATE | IC50 | > | 351000.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 201200.0 | nM | - |