Assay Detail
Functional
CHEMBL1764394
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells preincubated with compound for 1 hr before exposure to LPS measured after 24 hrs by Griess reaction method
21
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells by lignans isolated from Euonymus alatus leaves and twigs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 4.55 | 5.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1761712 | DEHYDROCONIFERYL ALCOHOL | — | 1 | 5.07 |
| CHEMBL406378 | — | — | 1 | 5.03 |
| CHEMBL261907 | DIHYDRODEHYDRODICONIFERY ALCOHOL | — | 1 | 5.01 |
| CHEMBL1761711 | — | — | 1 | 4.93 |
| CHEMBL253334 | — | — | 1 | 4.89 |
| CHEMBL361362 | SYRINGARESINOL | — | 1 | 4.83 |
| CHEMBL1761716 | — | — | 1 | 4.80 |
| CHEMBL1761831 | — | — | 1 | 4.67 |
| CHEMBL1761717 | HEDYOTOL C | — | 1 | 4.67 |
| CHEMBL1761709 | — | — | 1 | 4.38 |
| CHEMBL1761708 | — | — | 1 | 4.35 |
| CHEMBL7890 | L-NAME | 2.0 | 1 | 4.31 |
| CHEMBL1761710 | — | — | 1 | 4.26 |
| CHEMBL1760018 | — | — | 1 | 4.24 |
| CHEMBL1761714 | — | — | 1 | 4.24 |
| CHEMBL1760591 | — | — | 1 | 4.20 |
| CHEMBL1761713 | — | — | 1 | 4.20 |
| CHEMBL560169 | — | — | 1 | 4.18 |
| CHEMBL1761715 | — | — | 1 | 4.16 |
| CHEMBL1761832 | HEDYOTISOL B | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1761712 | DEHYDROCONIFERYL ALCOHOL | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL406378 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL261907 | DIHYDRODEHYDRODICONIFERY ALCOHOL | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1761711 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL253334 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL361362 | SYRINGARESINOL | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL1761716 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL1761831 | — | IC50 | = | 21300.0 | nM | 4.67 |
| CHEMBL1761717 | HEDYOTOL C | IC50 | = | 21400.0 | nM | 4.67 |
| CHEMBL1761709 | — | IC50 | = | 41900.0 | nM | 4.38 |
| CHEMBL1761708 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL7890 | L-NAME | IC50 | = | 48500.0 | nM | 4.31 |
| CHEMBL1761710 | — | IC50 | = | 55500.0 | nM | 4.26 |
| CHEMBL1760018 | — | IC50 | = | 58200.0 | nM | 4.24 |
| CHEMBL1761714 | — | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL1760591 | — | IC50 | = | 63400.0 | nM | 4.20 |
| CHEMBL1761713 | — | IC50 | = | 63600.0 | nM | 4.20 |
| CHEMBL560169 | — | IC50 | = | 66400.0 | nM | 4.18 |
| CHEMBL1761715 | — | IC50 | = | 69200.0 | nM | 4.16 |
| CHEMBL1761832 | HEDYOTISOL B | IC50 | > | 100000.0 | nM | - |
| CHEMBL1761832 | HEDYOTISOL B | IC50 | > | 100000.0 | nM | - |