Assay Detail
Binding
CHEMBL1764622
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Competitive inhibition of rat liver MAO-B after 60 mins using p-tyramine as substrate by spectrophotometry
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of selective and reversible pyrazoline based MAO-B inhibitors: virtual screening, synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 8.31 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1760721 | — | — | 1 | 9.35 |
| CHEMBL1760722 | — | — | 1 | 9.22 |
| CHEMBL1760715 | — | — | 1 | 8.68 |
| CHEMBL1760713 | — | — | 1 | 8.64 |
| CHEMBL1760717 | — | — | 1 | 8.46 |
| CHEMBL1760716 | — | — | 1 | 8.42 |
| CHEMBL1760719 | — | — | 1 | 8.32 |
| CHEMBL1760718 | — | — | 1 | 8.23 |
| CHEMBL1760714 | — | — | 1 | 8.17 |
| CHEMBL1760720 | — | — | 1 | 8.00 |
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1760721 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL1760722 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL1760715 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL1760713 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL1760717 | — | Ki | = | 3.43 | nM | 8.46 |
| CHEMBL1760716 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL1760719 | — | Ki | = | 4.77 | nM | 8.32 |
| CHEMBL1760718 | — | Ki | = | 5.91 | nM | 8.23 |
| CHEMBL1760714 | — | Ki | = | 6.75 | nM | 8.17 |
| CHEMBL1760720 | — | Ki | = | 9.91 | nM | 8.00 |
| CHEMBL972 | SELEGILINE | Ki | = | 1350.0 | nM | 5.87 |