Assay Detail
Binding
CHEMBL1764807
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Inhibition of human caspase 3 by fluorometric assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.01 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417149 | — | — | 1 | 8.66 |
| CHEMBL1762353 | — | — | 1 | 8.51 |
| CHEMBL1762350 | — | — | 1 | 8.48 |
| CHEMBL1762349 | — | — | 1 | 8.44 |
| CHEMBL1762363 | — | — | 1 | 8.35 |
| CHEMBL1762362 | — | — | 1 | 8.25 |
| CHEMBL1762357 | — | — | 1 | 8.22 |
| CHEMBL1762356 | — | — | 1 | 8.15 |
| CHEMBL1762360 | — | — | 1 | 8.12 |
| CHEMBL1762346 | — | — | 1 | 8.07 |
| CHEMBL456799 | — | — | 1 | 7.97 |
| CHEMBL1762361 | — | — | 1 | 7.96 |
| CHEMBL1762351 | — | — | 1 | 7.96 |
| CHEMBL1762364 | — | — | 1 | 7.92 |
| CHEMBL456798 | — | — | 1 | 7.91 |
| CHEMBL1762366 | — | — | 1 | 7.87 |
| CHEMBL1762352 | — | — | 1 | 7.86 |
| CHEMBL1762365 | — | — | 1 | 7.82 |
| CHEMBL1762358 | — | — | 1 | 7.74 |
| CHEMBL1762354 | — | — | 1 | 7.65 |
| CHEMBL1762359 | — | — | 1 | 7.63 |
| CHEMBL1762355 | — | — | 1 | 7.61 |
| CHEMBL1762348 | — | — | 1 | 7.57 |
| CHEMBL1762347 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417149 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL1762353 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL1762350 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1762349 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL1762363 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL1762362 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL1762357 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1762356 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL1762360 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1762346 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL456799 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL1762361 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1762351 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL1762364 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL456798 | — | IC50 | = | 12.2 | nM | 7.91 |
| CHEMBL1762366 | — | IC50 | = | 13.4 | nM | 7.87 |
| CHEMBL1762352 | — | IC50 | = | 13.7 | nM | 7.86 |
| CHEMBL1762365 | — | IC50 | = | 15.2 | nM | 7.82 |
| CHEMBL1762358 | — | IC50 | = | 18.3 | nM | 7.74 |
| CHEMBL1762354 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL1762359 | — | IC50 | = | 23.3 | nM | 7.63 |
| CHEMBL1762355 | — | IC50 | = | 24.4 | nM | 7.61 |
| CHEMBL1762348 | — | IC50 | = | 26.9 | nM | 7.57 |
| CHEMBL1762347 | — | IC50 | = | 27.9 | nM | 7.55 |