Assay Detail
Binding
CHEMBL1764819
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Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of the tyrosine kinase EphB4. Part 4: Discovery and optimization of a benzylic alcohol series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.58 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1762529 | — | — | 1 | 8.15 |
| CHEMBL1738764 | — | — | 1 | 8.15 |
| CHEMBL1762550 | — | — | 1 | 8.10 |
| CHEMBL1762525 | — | — | 1 | 8.00 |
| CHEMBL1762546 | — | — | 1 | 7.96 |
| CHEMBL1762537 | — | — | 1 | 7.96 |
| CHEMBL1762549 | — | — | 1 | 7.92 |
| CHEMBL1762524 | — | — | 1 | 7.92 |
| CHEMBL1762530 | — | — | 1 | 7.92 |
| CHEMBL1762548 | — | — | 1 | 7.89 |
| CHEMBL1762531 | — | — | 1 | 7.89 |
| CHEMBL1762547 | — | — | 1 | 7.85 |
| CHEMBL1762527 | — | — | 1 | 7.68 |
| CHEMBL1762543 | — | — | 1 | 7.64 |
| CHEMBL1762541 | — | — | 1 | 7.60 |
| CHEMBL1762536 | — | — | 1 | 7.57 |
| CHEMBL1762534 | — | — | 1 | 7.55 |
| CHEMBL1762538 | — | — | 1 | 7.55 |
| CHEMBL1762523 | — | — | 1 | 7.55 |
| CHEMBL1762522 | — | — | 1 | 7.55 |
| CHEMBL1762535 | — | — | 1 | 7.52 |
| CHEMBL1762539 | — | — | 1 | 7.50 |
| CHEMBL1762545 | — | — | 1 | 7.50 |
| CHEMBL1762544 | — | — | 1 | 7.46 |
| CHEMBL1762526 | — | — | 1 | 7.42 |
| CHEMBL1762533 | — | — | 1 | 7.39 |
| CHEMBL1762540 | — | — | 1 | 7.35 |
| CHEMBL1762521 | — | — | 1 | 7.08 |
| CHEMBL1762551 | — | — | 1 | 6.97 |
| CHEMBL1762528 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1762529 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1738764 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL1762550 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL1762525 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1762546 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1762537 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1762549 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1762524 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1762530 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1762548 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1762531 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1762547 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL1762527 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1762543 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL1762541 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1762536 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1762534 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1762522 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1762523 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1762538 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1762535 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1762539 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1762545 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL1762544 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1762526 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL1762533 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL1762540 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1762521 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL1762551 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL1762528 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL1762532 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL1762542 | — | IC50 | = | 459.0 | nM | 6.34 |