Compound Detail
CHEMBL1762535
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Basic Information
| ChEMBL ID | CHEMBL1762535 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DLGLTPBGHQDZCX-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
477.6
MW (Da)
3.06
ALogP
10
HBA
1
HBD
88.1
PSA (Ų)
0.55
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ephrin type-B receptor 4 CHEMBL5147 | IC50 | 8.7 | 8.11 | 2.0 | 2 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.85 | 6.85 | 140.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL279 | IC50 | 6.37 | 6.37 | 430.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ephrin type-B receptor 4 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human EPHB4 | 21441027 |
| Ephrin type-B receptor 4 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of human EphB4 autophosphorylation expressed in CHOK1 cells | 21441027 |
| Fibroblast growth factor receptor 1 | IC50 | = | 140.0 | nM | 6.85 | Inhibition FGFR1 | 21441027 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 430.0 | nM | 6.37 | Inhibition of VEGFR2 | 21441027 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21441027 | 10.1016/j.bmcl.2011.03.009 | Ephrin type-B receptor 4 | 2 |
| 21441027 | 10.1016/j.bmcl.2011.03.009 | Vascular endothelial growth factor receptor 2 | 1 |
| 21441027 | 10.1016/j.bmcl.2011.03.009 | Fibroblast growth factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine