Assay Detail
Functional
CHEMBL1767475
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate intracellular accumulation by scintillation proximity assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structural modifications of UMP, UDP, and UTP leading to subtype-selective agonists for P2Y2, P2Y4, and P2Y6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 27 | 5.57 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1767409 | — | — | 1 | 7.64 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.05 |
| CHEMBL1767410 | — | — | 1 | 5.82 |
| CHEMBL519835 | — | — | 1 | 5.42 |
| CHEMBL1765118 | — | — | 1 | 5.41 |
| CHEMBL1767418 | — | — | 1 | 5.36 |
| CHEMBL1767414 | — | — | 1 | 5.35 |
| CHEMBL1767411 | — | — | 1 | 5.31 |
| CHEMBL1233534 | — | — | 1 | 5.30 |
| CHEMBL1767412 | — | — | 1 | 5.22 |
| CHEMBL1765115 | — | — | 1 | 5.14 |
| CHEMBL1765116 | — | — | 1 | 5.10 |
| CHEMBL1765119 | — | — | 1 | 5.03 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | 4.85 |
| CHEMBL1767422 | — | — | 1 | - |
| CHEMBL1767421 | — | — | 1 | - |
| CHEMBL1767423 | — | — | 1 | - |
| CHEMBL1230331 | — | — | 1 | - |
| CHEMBL1765114 | — | — | 1 | - |
| CHEMBL1767420 | — | — | 1 | - |
| CHEMBL1767419 | — | — | 1 | - |
| CHEMBL1767417 | — | — | 1 | - |
| CHEMBL1765117 | — | — | 1 | - |
| CHEMBL1767416 | — | — | 1 | - |
| CHEMBL1767415 | — | — | 1 | - |
| CHEMBL1765120 | — | — | 1 | - |
| CHEMBL1767413 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1767409 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 88.4 | nM | 7.05 |
| CHEMBL1767410 | — | EC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL519835 | — | EC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL1765118 | — | EC50 | = | 3930.0 | nM | 5.41 |
| CHEMBL1767418 | — | EC50 | = | 4330.0 | nM | 5.36 |
| CHEMBL1767414 | — | EC50 | = | 4490.0 | nM | 5.35 |
| CHEMBL1767411 | — | EC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL1233534 | — | EC50 | = | 4980.0 | nM | 5.30 |
| CHEMBL1767412 | — | EC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL1765115 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1765116 | — | EC50 | = | 7870.0 | nM | 5.10 |
| CHEMBL1765119 | — | EC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1767422 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767421 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767423 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1230331 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1765114 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL1767420 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767419 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767417 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1765117 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767416 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL1767415 | — | EC50 | >= | 100000.0 | nM | - |
| CHEMBL1765120 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1767413 | — | EC50 | >= | 100000.0 | nM | - |