Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL336296

URIDINE TRIPHOSPHATE
🧪 Phase III
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
🧪 Phase III
O=c1ccn([C@@H]2O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL336296
Name URIDINE TRIPHOSPHATE
Phase Phase III
Structure Type MOL
InChI Key PGAVKCOVUIYSFO-XVFCMESISA-N

Known Names

INS-316 INS316 Uridine 5'-triphosphate Uridine triphosphate Uridine-5'-triphosphate Utp
7
Targets
68
Activities
3
Assay Types
2
PK Parameters
20
Publications
6
Known Names
2
Indications

Molecular Properties

484.1
MW (Da)
-2.50
ALogP
12
HBA
7
HBD
264.4
PSA (Ų)
0.19
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Single Enantiomer

Flags

Natural Product

Extended Properties

Molecular Formula C9H15N2O15P3
MW 484.14
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 1.45

Indications

Lung Neoplasms Lung Diseases, Interstitial

Activity Summary

EC50 63 meas. best 8.25
Ki 4 meas. best 4.0
IC50 1 meas. best 5.82

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 2
CHEMBL4398
 EC50 8.25 6.9253 5.6 40
P2Y purinoceptor 4
CHEMBL2123
 EC50 7.41 6.7606 39.0 16
P2Y purinoceptor 2
CHEMBL4419
 EC50 6.89 6.89 130.0 1
P2Y purinoceptor 6
CHEMBL4714
 EC50 6.37 5.6033 424.0 3
Unchecked
CHEMBL612545
 EC50 6.37 6.37 424.0 1
P2Y purinoceptor 2
CHEMBL1075298
 EC50 5.9 5.9 1260.0 1
P2Y purinoceptor 2
CHEMBL1075298
 IC50 5.82 5.82 1510.0 1
P2Y purinoceptor 4
CHEMBL2124
 EC50 5.58 5.58 2600.0 1
Unchecked
CHEMBL612545
 Ki 4.0 4.0 100000.0 2

Pharmacokinetic Data

Parameter Value Units Species
T1/2 31.0 hr -
T1/2 23.0 hr -

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
P2Y purinoceptor 2 EC50 = 5.61 nM 8.25 Agonist activity at wild type P2Y2 receptor (unknown origin) expressed in human ... 28938069
P2Y purinoceptor 2 EC50 = 7.0 nM 8.15 Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay 17079144
P2Y purinoceptor 2 EC50 = 7.0 nM 8.15 Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay 17011188
P2Y purinoceptor 2 EC50 = 17.9 nM 7.75 Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 ce... 21417463
P2Y purinoceptor 2 EC50 = 20.0 nM 7.7 Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed... 22386981
P2Y purinoceptor 2 EC50 = 30.0 nM 7.52 Agonist activity evaluated as change in the level of cytosolic calcium in 1321N ... 11206448
P2Y purinoceptor 2 EC50 = 37.2 nM 7.43 Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y114A mutan... 19419204
P2Y purinoceptor 4 EC50 = 39.0 nM 7.41 Agonist activity at human cloned P2Y4 receptor expressed in human 1321N1 by FLIP... 17011188
P2Y purinoceptor 4 EC50 = 39.0 nM 7.41 Agonist activity at human cloned P2Y4 receptor expressed in human 1321N1 by FLIP... 17079144
P2Y purinoceptor 2 EC50 = 43.0 nM 7.37 Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP... 17125260
P2Y purinoceptor 2 EC50 = 49.0 nM 7.31 Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells as... 17302398
P2Y purinoceptor 2 EC50 = 50.1 nM 7.3 Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A mutan... 19419204
P2Y purinoceptor 2 EC50 = 55.0 nM 7.26 Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 ce... 21528910
P2Y purinoceptor 2 EC50 = 59.0 nM 7.23 Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor... 19419204
P2Y purinoceptor 2 EC50 = 60.0 nM 7.22 Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed... 18514530
P2Y purinoceptor 2 EC50 = 60.0 nM 7.22 Agonist activity at human recombinant P2Y2 receptor expressed in human 1321N1 ce... 20446735
P2Y purinoceptor 2 EC50 = 60.0 nM 7.22 Agonist activity at human P2Y2 21528910
P2Y purinoceptor 2 EC50 = 70.6 nM 7.15 Agonist activity at P2Y2 receptor S193A mutant (unknown origin) expressed in hum... 28938069
P2Y purinoceptor 4 EC50 = 73.0 nM 7.14 Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells as... 17302398
P2Y purinoceptor 4 EC50 = 80.0 nM 7.1 Agonist activity at human recombinant P2Y4 receptor expressed in human 1321N1 ce... 21528910

Literature References

PubMed DOI Target Context # Activities
19419204 10.1021/jm801442p P2Y purinoceptor 2 28
28938069 10.1021/acs.jmedchem.7b00854 Unchecked 16
28938069 10.1021/acs.jmedchem.7b00854 P2Y purinoceptor 2 12
- 10.6019/CHEMBL4495565 SARS-CoV-2 6
29254895 10.1016/j.bmc.2017.11.043 P2Y purinoceptor 2 5
17101674 10.1128/aac.00400-06 Unchecked 4
29681152 10.1021/acs.jmedchem.7b01906 No relevant target 4
- 10.6019/CHEMBL4495564 Replicase polyprotein 1ab 3
16509585 10.1021/jm051064t RNA-directed RNA polymerase 3
21528910 10.1021/jm101591j P2Y purinoceptor 2 3
19523835 10.1016/j.bmc.2009.05.062 P2Y purinoceptor 2 3
- 10.1016/S0960-894X(00)80055-4 Beta-1,4-galactosyltransferase 1 2
20446735 10.1021/jm100287t P2Y purinoceptor 6 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
16539385 10.1021/jm050955y P2Y purinoceptor 2 2
17329110 10.1016/j.bmc.2007.02.014 Unchecked 2
21528910 10.1021/jm101591j P2Y purinoceptor 4 2
12213051 10.1021/jm020046y P2Y purinoceptor 4 2
17101674 10.1128/aac.00400-06 RNA-directed RNA polymerase 2
8904648 10.1111/j.1476-5381.1996.tb15733.x Unchecked 1

Data from ChEMBL 36 via Core Engine