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Assay Detail

CHEMBL902429

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Functional
Agonist activity at human P2Y2 receptor expressed in human 1321N1 by FLIPR assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

P2Y purinoceptor 2 (CHEMBL4398)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Novel nucleotide triphosphates as potent P2Y2 agonists with enhanced stability over UTP.
Davenport RJ, Diaz P, Galvin FC, Lloyd S, Mack SR, Owens R, Sabin V, Wynn J.
Bioorg Med Chem Lett (2007) 17 : 558 -561
PubMed 17079144 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 7.59 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL241483 1 8.52
CHEMBL399017 1 8.30
CHEMBL336296 URIDINE TRIPHOSPHATE 3.0 1 8.15
CHEMBL392989 1 8.15
CHEMBL241482 1 8.10
CHEMBL391317 1 8.00
CHEMBL241481 1 7.66
CHEMBL238957 1 7.38
CHEMBL391318 1 6.70
CHEMBL240044 1 6.41
CHEMBL240043 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL241483 EC50 = 3.0 nM 8.52
CHEMBL399017 EC50 = 5.0 nM 8.30
CHEMBL336296 URIDINE TRIPHOSPHATE EC50 = 7.0 nM 8.15
CHEMBL392989 EC50 = 7.0 nM 8.15
CHEMBL241482 EC50 = 8.0 nM 8.10
CHEMBL391317 EC50 = 10.0 nM 8.00
CHEMBL241481 EC50 = 22.0 nM 7.66
CHEMBL238957 EC50 = 42.0 nM 7.38
CHEMBL391318 EC50 = 200.0 nM 6.70
CHEMBL240044 EC50 = 390.0 nM 6.41
CHEMBL240043 EC50 = 700.0 nM 6.16