Assay Detail
Functional
CHEMBL907213
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y2 receptor expressed in 1321N1 cells assessed as IP accumulation by SPA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 6.54 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.37 |
| CHEMBL217803 | — | — | 1 | 7.30 |
| CHEMBL384527 | — | — | 1 | 6.46 |
| CHEMBL217467 | — | — | 1 | 6.45 |
| CHEMBL215783 | — | — | 1 | 6.25 |
| CHEMBL214698 | — | — | 1 | 5.43 |
| CHEMBL385488 | — | — | 1 | - |
| CHEMBL386096 | — | — | 1 | - |
| CHEMBL215294 | — | — | 1 | - |
| CHEMBL215447 | — | — | 1 | - |
| CHEMBL216011 | — | — | 1 | - |
| CHEMBL217370 | — | — | 1 | - |
| CHEMBL265170 | — | — | 1 | - |
| CHEMBL425805 | — | — | 1 | - |
| CHEMBL413841 | — | — | 1 | - |
| CHEMBL436959 | — | — | 1 | - |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | - |
| CHEMBL385506 | — | — | 1 | - |
| CHEMBL217391 | — | — | 1 | - |
| CHEMBL215263 | — | — | 1 | - |
| CHEMBL383923 | — | — | 1 | - |
| CHEMBL214830 | — | — | 1 | - |
| CHEMBL215381 | — | — | 1 | - |
| CHEMBL215940 | — | — | 1 | - |
| CHEMBL384771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL217803 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL384527 | — | EC50 | = | 347.0 | nM | 6.46 |
| CHEMBL217467 | — | EC50 | = | 354.0 | nM | 6.45 |
| CHEMBL215783 | — | EC50 | = | 564.0 | nM | 6.25 |
| CHEMBL214698 | — | EC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL385488 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL386096 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL215294 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL215447 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL216011 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL217370 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL265170 | — | EC50 | <= | 1000.0 | nM | - |
| CHEMBL425805 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL413841 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL436959 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | - | — | - | |
| CHEMBL385506 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL217391 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL215263 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL383923 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL214830 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL215381 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL215940 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL384771 | — | EC50 | >= | 100000.0 | nM | - |