Assay Detail
Functional
CHEMBL1786811
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Agonist activity at human P2Y2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrimidine nucleotides with 4-alkyloxyimino and terminal tetraphosphate δ-ester modifications as selective agonists of the P2Y(4) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.25 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL373780 | — | — | 1 | 8.10 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.22 |
| CHEMBL499138 | — | — | 1 | 6.52 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | 4.0 | 1 | 5.88 |
| CHEMBL474886 | — | — | 1 | 5.72 |
| CHEMBL502712 | — | — | 1 | 5.64 |
| CHEMBL519835 | — | — | 1 | 5.60 |
| CHEMBL1784888 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL373780 | — | EC50 | = | 8.0 | nM | 8.10 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL499138 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL1767408 | DIQUAFOSOL TETRASODIUM | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL474886 | — | EC50 | = | 1890.0 | nM | 5.72 |
| CHEMBL502712 | — | EC50 | = | 2270.0 | nM | 5.64 |
| CHEMBL519835 | — | EC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL1784888 | — | EC50 | = | 5000.0 | nM | 5.30 |