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Compound Detail

CHEMBL373780

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N[C@@H]1[C@H](O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]1n1ccc(=O)[nH]c1=S

Basic Information

ChEMBL ID CHEMBL373780
Phase Preclinical
Structure Type MOL
InChI Key UWTUUIWWVPWHAA-XVFCMESISA-N
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
8
Publications
0
Known Names

Molecular Properties

499.2
MW (Da)
-1.17
ALogP
12
HBA
7
HBD
253.1
PSA (Ų)
0.16
QED
2
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H16N3O13P3S
MW 499.22
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 1.06

Activity Summary

EC50 6 meas. best 8.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
P2Y purinoceptor 2
CHEMBL4398
EC50 8.1 8.1 8.0 4
P2Y purinoceptor 4
CHEMBL2123
EC50 5.62 5.62 2400.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17302398 10.1021/jm060903o P2Y purinoceptor 2 1
17302398 10.1021/jm060903o P2Y purinoceptor 4 1
17302398 10.1021/jm060903o P2Y purinoceptor 6 1
18514530 10.1016/j.bmc.2008.05.013 P2Y purinoceptor 2 1
18514530 10.1016/j.bmc.2008.05.013 P2Y purinoceptor 4 1
18514530 10.1016/j.bmc.2008.05.013 P2Y purinoceptor 6 1
20095577 10.1021/jm901450d P2Y purinoceptor 2 1
21528910 10.1021/jm101591j P2Y purinoceptor 2 1

Data from ChEMBL 36 via Core Engine