Assay Detail
Functional
CHEMBL958068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 5.89 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503798 | — | — | 1 | 7.10 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.05 |
| CHEMBL519835 | — | — | 1 | 7.05 |
| CHEMBL221326 | DIQUAFOSOL | 4.0 | 1 | 6.89 |
| CHEMBL507282 | DENUFOSOL | 3.0 | 1 | 6.85 |
| CHEMBL521451 | — | — | 1 | 6.55 |
| CHEMBL217803 | — | — | 1 | 6.46 |
| CHEMBL505403 | — | — | 1 | 6.27 |
| CHEMBL509434 | — | — | 1 | 6.15 |
| CHEMBL239151 | — | — | 1 | 6.06 |
| CHEMBL482895 | — | — | 1 | 5.95 |
| CHEMBL385098 | — | — | 1 | 5.92 |
| CHEMBL521487 | — | — | 1 | 5.90 |
| CHEMBL444212 | — | — | 1 | 5.75 |
| CHEMBL484105 | — | — | 1 | 5.71 |
| CHEMBL499138 | — | — | 1 | 5.69 |
| CHEMBL373780 | — | — | 1 | 5.62 |
| CHEMBL483913 | — | — | 1 | 5.60 |
| CHEMBL519991 | — | — | 1 | 5.57 |
| CHEMBL454230 | — | — | 1 | 5.37 |
| CHEMBL484295 | — | — | 1 | 5.33 |
| CHEMBL483502 | — | — | 1 | 5.33 |
| CHEMBL448985 | — | — | 1 | 5.32 |
| CHEMBL482683 | — | — | 1 | 5.28 |
| CHEMBL482472 | — | — | 1 | 5.27 |
| CHEMBL482485 | — | — | 1 | 5.26 |
| CHEMBL500840 | — | — | 1 | 5.20 |
| CHEMBL484494 | — | — | 1 | 5.10 |
| CHEMBL484290 | — | — | 1 | 5.09 |
| CHEMBL508122 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503798 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL519835 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL221326 | DIQUAFOSOL | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL507282 | DENUFOSOL | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL521451 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL217803 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL505403 | — | EC50 | = | 540.0 | nM | 6.27 |
| CHEMBL509434 | — | EC50 | = | 710.0 | nM | 6.15 |
| CHEMBL239151 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL482895 | — | EC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL385098 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL521487 | — | EC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL444212 | — | EC50 | = | 1770.0 | nM | 5.75 |
| CHEMBL484105 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL499138 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL373780 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL483913 | — | EC50 | = | 2530.0 | nM | 5.60 |
| CHEMBL519991 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL454230 | — | EC50 | = | 4320.0 | nM | 5.37 |
| CHEMBL484295 | — | EC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL483502 | — | EC50 | = | 4640.0 | nM | 5.33 |
| CHEMBL448985 | — | EC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL482683 | — | EC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL482472 | — | EC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL482485 | — | EC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL500840 | — | EC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL484494 | — | EC50 | = | 7930.0 | nM | 5.10 |
| CHEMBL484290 | — | EC50 | = | 8110.0 | nM | 5.09 |
| CHEMBL508122 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL474887 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL502712 | — | EC50 | > | 10000.0 | nM | - |