Assay Detail
Functional
CHEMBL697057
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity evaluated as change in the level of cytosolic calcium in 1321N astrocytoma cells infected with a retrovirus encoding the human P2Y2 receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and P2Y receptor activity of a series of uridine dinucleoside 5'-polyphosphates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.75 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.52 |
| CHEMBL1207447 | — | — | 1 | 7.00 |
| CHEMBL2113401 | — | — | 1 | 5.25 |
| CHEMBL2113398 | — | — | 1 | 5.08 |
| CHEMBL2113465 | — | — | 1 | 5.01 |
| CHEMBL1162193 | — | — | 1 | 4.66 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1207447 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2113401 | — | EC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL2113398 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2113465 | — | EC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL1162193 | — | EC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL130266 | URIDINE_DIPHOSPHATE | EC50 | > | 10000.0 | nM | - |