Assay Detail
Functional
CHEMBL1960464
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as stimulation of PLC-induced [3H]inositol phosphate production after 30 mins by scintillation counting
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 1321-N1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and P2Y₂ receptor agonist activities of uridine 5'-phosphonate analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.03 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | 3.0 | 1 | 7.70 |
| CHEMBL1957440 | — | — | 1 | 6.40 |
| CHEMBL1957444 | — | — | 1 | 6.30 |
| CHEMBL1957443 | — | — | 1 | 6.16 |
| CHEMBL1957442 | — | — | 1 | 6.00 |
| CHEMBL1957438 | — | — | 1 | 5.82 |
| CHEMBL1957439 | — | — | 1 | 5.68 |
| CHEMBL1957441 | — | — | 1 | 5.51 |
| CHEMBL1957448 | — | — | 1 | 5.40 |
| CHEMBL522015 | — | — | 1 | 5.29 |
| CHEMBL1957447 | — | — | 1 | - |
| CHEMBL1957446 | — | — | 1 | - |
| CHEMBL1957445 | — | — | 1 | - |
| CHEMBL1957449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336296 | URIDINE TRIPHOSPHATE | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1957440 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL1957444 | — | EC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1957443 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1957442 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1957438 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1957439 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL1957441 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL1957448 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL522015 | — | EC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL1957447 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1957446 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1957445 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL1957449 | — | EC50 | > | 20000.0 | nM | - |