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Target Snapshot

CHEMBL2124 Target Snapshot

P2Y purinoceptor 4 · SINGLE PROTEIN · Rattus norvegicus

5Compounds
5Assays
0Approved Drugs
5.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt O35811. Use UniProt O35811 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O35811 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats P2Y purinoceptor 4 as ChEMBL target CHEMBL2124, mapped to UniProt O35811. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
P2Y purinoceptor 4
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL2124
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
O35811
P2Y purinoceptor 4
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether P2Y purinoceptor 4 is the right protein anchor across sources, using UniProt O35811 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelP2Y purinoceptor 4
UniProt AccessionO35811
Component TypeProtein
Sequence Length361 aa

P2Y purinoceptor 4

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as P2Y purinoceptor 4, mapped to UniProt O35811. Sequence length is 361 aa.

Mapped IDO35811
Review nameP2Y purinoceptor 4
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

EC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL14249 5.93 EC50 1170.0 Clinical
CHEMBL336296 5.58 EC50 2600.0 Clinical
CHEMBL339385 5.52 EC50 3000.0 Preclinical
CHEMBL223344 5.19 EC50 6430.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
4
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
3
Tested Compounds
2
Assay Types
Binding — 3 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 1 5.2
single protein format 1 1 5.9
Functional — 2 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 3 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine