Assay Detail
Binding
CHEMBL1767487
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Irreversible inhibition of Methanobacterium thermoautotrophicum 5'-monophosphate decarboxylase
7
Total Activities
3
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Methanothermobacter thermautotrophicus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Orotidine 5'-phosphate decarboxylase (CHEMBL5688) ↗| Type | SINGLE PROTEIN |
| Organism | Methanobacterium thermoautotrophicum |
Publication
Novel interactions of fluorinated nucleotide derivatives targeting orotidine 5'-monophosphate decarboxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 6.20 | 6.20 |
| Kinact | 3 | - | - |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765125 | — | — | 2 | 6.20 |
| CHEMBL1765126 | — | — | 2 | - |
| CHEMBL1765124 | — | — | 3 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765125 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL1765126 | — | Ki | = | 1200000.0 | nM | - |
| CHEMBL1765124 | — | Ki | = | 30000000.0 | nM | - |
| CHEMBL1765125 | — | Kinact | = | 612.0 | /hr | - |
| CHEMBL1765126 | — | Kinact | = | 4.0 | /hr | - |
| CHEMBL1765124 | — | Kinact | = | 2.0 | /hr | - |
| CHEMBL1765124 | — | Inhibition | - | % | - |