Assay Detail
Binding
CHEMBL1767579
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of nNOS expressed in human 293T cells assessed as nitrite formation after 8 hrs by Griess reaction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | 293T |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Symmetric double-headed aminopyridines, a novel strategy for potent and membrane-permeable inhibitors of neuronal nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.30 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1615288 | — | — | 1 | 5.30 |
| CHEMBL480419 | — | — | 1 | - |
| CHEMBL594682 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1615288 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL480419 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL594682 | — | IC50 | > | 10000.0 | nM | - |