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Assay Detail

CHEMBL1767585

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assay
ChEMBL ↗
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Serine/threonine-protein kinase ATR (CHEMBL5024) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.
Charrier JD, Durrant SJ, Golec JM, Kay DP, Knegtel RM, MacCormick S, Mortimore M, O'Donnell ME, Pinder JL, Reaper PM, Rutherford AP, Wang PS, Young SC, Pollard JR.
J Med Chem (2011) 54 : 2320 -2330
PubMed 21413798 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 51 6.71 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1766796 — — 1 8.22
CHEMBL1766798 — — 1 8.10
CHEMBL1766793 — — 1 8.10
CHEMBL1766799 — — 1 8.00
CHEMBL1766795 — — 1 8.00
CHEMBL1766797 — — 1 7.92
CHEMBL1766792 — — 1 7.92
CHEMBL1766794 — — 1 7.85
CHEMBL1766803 — — 1 7.66
CHEMBL1766804 — — 1 7.64
CHEMBL1766765 — — 1 7.62
CHEMBL1766779 — — 1 7.58
CHEMBL1766789 — — 1 7.58
CHEMBL1766801 — — 1 7.52
CHEMBL1766802 — — 1 7.44
CHEMBL1766790 — — 1 7.32
CHEMBL1766788 — — 1 7.27
CHEMBL1766787 — — 1 7.27
CHEMBL1766791 — — 1 7.25
CHEMBL1766786 — — 1 7.00
CHEMBL1766784 — — 1 6.96
CHEMBL1766766 — — 1 6.89
CHEMBL1766778 — — 1 6.75
CHEMBL1766785 — — 1 6.75
CHEMBL1765107 — — 1 6.75
CHEMBL1766780 — — 1 6.50
CHEMBL1766773 — — 1 6.47
CHEMBL1766772 — — 1 6.40
CHEMBL1766774 — — 1 6.27
CHEMBL1766777 — — 1 6.25

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1766796 — IC50 = 6.0 nM 8.22
CHEMBL1766798 — IC50 = 8.0 nM 8.10
CHEMBL1766793 — IC50 = 8.0 nM 8.10
CHEMBL1766799 — IC50 = 10.0 nM 8.00
CHEMBL1766795 — IC50 = 10.0 nM 8.00
CHEMBL1766797 — IC50 = 12.0 nM 7.92
CHEMBL1766792 — IC50 = 12.0 nM 7.92
CHEMBL1766794 — IC50 = 14.0 nM 7.85
CHEMBL1766803 — IC50 = 22.0 nM 7.66
CHEMBL1766804 — IC50 = 23.0 nM 7.64
CHEMBL1766765 — IC50 = 24.0 nM 7.62
CHEMBL1766779 — IC50 = 26.0 nM 7.58
CHEMBL1766789 — IC50 = 26.0 nM 7.58
CHEMBL1766801 — IC50 = 30.0 nM 7.52
CHEMBL1766802 — IC50 = 36.0 nM 7.44
CHEMBL1766790 — IC50 = 48.0 nM 7.32
CHEMBL1766788 — IC50 = 54.0 nM 7.27
CHEMBL1766787 — IC50 = 54.0 nM 7.27
CHEMBL1766791 — IC50 = 56.0 nM 7.25
CHEMBL1766786 — IC50 = 100.0 nM 7.00
CHEMBL1766784 — IC50 = 110.0 nM 6.96
CHEMBL1766766 — IC50 = 130.0 nM 6.89
CHEMBL1766778 — IC50 = 180.0 nM 6.75
CHEMBL1766785 — IC50 = 180.0 nM 6.75
CHEMBL1765107 — IC50 = 180.0 nM 6.75
CHEMBL1766780 — IC50 = 320.0 nM 6.50
CHEMBL1766773 — IC50 = 340.0 nM 6.47
CHEMBL1766772 — IC50 = 400.0 nM 6.40
CHEMBL1766774 — IC50 = 540.0 nM 6.27
CHEMBL1766777 — IC50 = 560.0 nM 6.25
CHEMBL1766759 — IC50 = 620.0 nM 6.21
CHEMBL1766764 — IC50 = 640.0 nM 6.19
CHEMBL1766770 — IC50 = 700.0 nM 6.16
CHEMBL1766769 — IC50 = 740.0 nM 6.13
CHEMBL1766767 — IC50 = 1300.0 nM 5.89
CHEMBL1766771 — IC50 = 1400.0 nM 5.85
CHEMBL1766781 — IC50 = 1500.0 nM 5.82
CHEMBL1766776 — IC50 = 1600.0 nM 5.80
CHEMBL1766783 — IC50 = 1700.0 nM 5.77
CHEMBL1766763 — IC50 = 2100.0 nM 5.68
CHEMBL1766775 — IC50 = 2200.0 nM 5.66
CHEMBL1766768 — IC50 = 2400.0 nM 5.62
CHEMBL1766782 — IC50 = 2400.0 nM 5.62
CHEMBL1766762 — IC50 = 3000.0 nM 5.52
CHEMBL1766800 — IC50 = 3560.0 nM 5.45
CHEMBL1766761 — IC50 = 5200.0 nM 5.28
CHEMBL1766760 — IC50 = 7100.0 nM 5.15
CHEMBL479488 SCHISANDRIN B IC50 = 7200.0 nM 5.14
CHEMBL222102 KU-55933 IC50 > 100000.0 nM -
CHEMBL113 CAFFEINE IC50 = 1100000.0 nM -