Assay Detail
Functional
CHEMBL1767668
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Inhibition of LPS/IFNgamma-induced NO production in mouse RAW264.7 cells after 24 hrs by Griess reagent method
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.76 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL476372 | — | — | 1 | 7.75 |
| CHEMBL476362 | — | — | 1 | 7.26 |
| CHEMBL478658 | — | — | 1 | 6.80 |
| CHEMBL479254 | — | — | 1 | 6.70 |
| CHEMBL516722 | — | — | 1 | 6.64 |
| CHEMBL514199 | — | — | 1 | 6.64 |
| CHEMBL518278 | — | — | 1 | 6.54 |
| CHEMBL476151 | — | — | 1 | 6.36 |
| CHEMBL478659 | — | — | 1 | 6.33 |
| CHEMBL476361 | — | — | 1 | 6.14 |
| CHEMBL518263 | — | — | 1 | 6.09 |
| CHEMBL516105 | — | — | 1 | 6.03 |
| CHEMBL1766568 | — | — | 1 | 5.89 |
| CHEMBL450543 | — | — | 1 | 5.86 |
| CHEMBL476749 | — | — | 1 | 5.76 |
| CHEMBL476958 | — | — | 1 | 5.76 |
| CHEMBL476959 | — | — | 1 | 5.66 |
| CHEMBL476371 | — | — | 1 | 5.64 |
| CHEMBL515474 | — | — | 1 | 5.60 |
| CHEMBL476997 | — | — | 1 | 5.60 |
| CHEMBL518576 | — | — | 1 | 5.60 |
| CHEMBL476139 | — | — | 1 | 5.47 |
| CHEMBL516893 | — | — | 1 | 5.47 |
| CHEMBL516723 | — | — | 1 | 5.47 |
| CHEMBL477388 | — | — | 1 | 5.44 |
| CHEMBL518438 | — | — | 1 | 5.38 |
| CHEMBL477389 | — | — | 1 | 5.22 |
| CHEMBL478863 | — | — | 1 | 5.09 |
| CHEMBL514830 | — | — | 1 | 4.98 |
| CHEMBL477809 | — | — | 1 | 4.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL476372 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL476362 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL478658 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL479254 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL516722 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL514199 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL518278 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL476151 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL478659 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL476361 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL518263 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL516105 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL1766568 | — | IC50 | = | 1280.0 | nM | 5.89 |
| CHEMBL450543 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL476958 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL476749 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL476959 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL476371 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL476997 | — | IC50 | = | 2490.0 | nM | 5.60 |
| CHEMBL518576 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL515474 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL476139 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL516893 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL516723 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL477388 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL518438 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL477389 | — | IC50 | = | 6060.0 | nM | 5.22 |
| CHEMBL478863 | — | IC50 | = | 8130.0 | nM | 5.09 |
| CHEMBL514830 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL477809 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL476089 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL479236 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL478657 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL476088 | — | IC50 | = | 16500.0 | nM | 4.78 |
| CHEMBL1766570 | AMTOLMETIN GUACIL | IC50 | = | 51300.0 | nM | 4.29 |