Assay Detail
ADMET
CHEMBL1767669
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Cytotoxicity against mouse RAW264.7 cells assessed as cell viability after 4 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.08 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766568 | — | — | 1 | 8.22 |
| CHEMBL476089 | — | — | 1 | 6.75 |
| CHEMBL479254 | — | — | 1 | 6.72 |
| CHEMBL518278 | — | — | 1 | 5.80 |
| CHEMBL479236 | — | — | 1 | 5.35 |
| CHEMBL476139 | — | — | 1 | 5.18 |
| CHEMBL478658 | — | — | 1 | 5.00 |
| CHEMBL476371 | — | — | 1 | 5.00 |
| CHEMBL476958 | — | — | 1 | 4.97 |
| CHEMBL516105 | — | — | 1 | 4.96 |
| CHEMBL476749 | — | — | 1 | 4.94 |
| CHEMBL476997 | — | — | 1 | 4.90 |
| CHEMBL476088 | — | — | 1 | 4.77 |
| CHEMBL518576 | — | — | 1 | 4.76 |
| CHEMBL476372 | — | — | 1 | 4.61 |
| CHEMBL476959 | — | — | 1 | 4.47 |
| CHEMBL478657 | — | — | 1 | 4.46 |
| CHEMBL514199 | — | — | 1 | 4.32 |
| CHEMBL518263 | — | — | 1 | 4.27 |
| CHEMBL476151 | — | — | 1 | 4.25 |
| CHEMBL476361 | — | — | 1 | 4.11 |
| CHEMBL514830 | — | — | 1 | 4.04 |
| CHEMBL518438 | — | — | 1 | - |
| CHEMBL477389 | — | — | 1 | - |
| CHEMBL478659 | — | — | 1 | - |
| CHEMBL450543 | — | — | 1 | - |
| CHEMBL477388 | — | — | 1 | - |
| CHEMBL515474 | — | — | 1 | - |
| CHEMBL516722 | — | — | 1 | - |
| CHEMBL476362 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766568 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL476089 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL479254 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL518278 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL479236 | — | IC50 | = | 4460.0 | nM | 5.35 |
| CHEMBL476139 | — | IC50 | = | 6560.0 | nM | 5.18 |
| CHEMBL478658 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL476371 | — | IC50 | = | 9950.0 | nM | 5.00 |
| CHEMBL476958 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL516105 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL476749 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL476997 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL476088 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL518576 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL476372 | — | IC50 | = | 24300.0 | nM | 4.61 |
| CHEMBL476959 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL478657 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL514199 | — | IC50 | = | 47700.0 | nM | 4.32 |
| CHEMBL518263 | — | IC50 | = | 53200.0 | nM | 4.27 |
| CHEMBL476151 | — | IC50 | = | 56900.0 | nM | 4.25 |
| CHEMBL476361 | — | IC50 | = | 78000.0 | nM | 4.11 |
| CHEMBL514830 | — | IC50 | = | 91300.0 | nM | 4.04 |
| CHEMBL1766570 | AMTOLMETIN GUACIL | IC50 | - | — | - | |
| CHEMBL478863 | — | IC50 | = | 2060000.0 | nM | - |
| CHEMBL516723 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL477809 | — | IC50 | = | 2810000.0 | nM | - |
| CHEMBL516893 | — | IC50 | = | 1860000.0 | nM | - |
| CHEMBL476362 | — | IC50 | = | 110000.0 | nM | - |
| CHEMBL516722 | — | IC50 | - | — | - | |
| CHEMBL515474 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL477388 | — | IC50 | = | 148000.0 | nM | - |
| CHEMBL450543 | — | IC50 | - | — | - | |
| CHEMBL478659 | — | IC50 | = | 6830000.0 | nM | - |
| CHEMBL477389 | — | IC50 | = | 1440000.0 | nM | - |
| CHEMBL518438 | — | IC50 | = | 111000.0 | nM | - |