Assay Detail
Functional
CHEMBL1767787
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Cytotoxicity against human HCT116 cells expressing p53 after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.04 | 5.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1610049 | — | — | 1 | 5.24 |
| CHEMBL1766683 | — | — | 1 | 5.20 |
| CHEMBL1766690 | — | — | 1 | 5.17 |
| CHEMBL1462900 | — | — | 1 | 5.16 |
| CHEMBL1363219 | — | — | 1 | 5.14 |
| CHEMBL1766685 | — | — | 1 | 5.14 |
| CHEMBL1766688 | — | — | 1 | 5.12 |
| CHEMBL1766693 | — | — | 1 | 5.11 |
| CHEMBL1621541 | — | — | 1 | 5.11 |
| CHEMBL1766689 | — | — | 1 | 5.08 |
| CHEMBL1766692 | — | — | 1 | 5.05 |
| CHEMBL1766686 | — | — | 1 | 4.98 |
| CHEMBL1766695 | — | — | 1 | 4.92 |
| CHEMBL1766681 | — | — | 1 | 4.90 |
| CHEMBL1766694 | — | — | 1 | 4.85 |
| CHEMBL1766687 | — | — | 1 | 4.82 |
| CHEMBL1766684 | — | — | 1 | 4.76 |
| CHEMBL1766682 | — | — | 1 | - |
| CHEMBL1766691 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1610049 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1766683 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL1766690 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1462900 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1363219 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1766685 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL1766688 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL1766693 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1621541 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL1766689 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL1766692 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL1766686 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL1766695 | — | IC50 | = | 11900.0 | nM | 4.92 |
| CHEMBL1766681 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL1766694 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL1766687 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL1766684 | — | IC50 | = | 17300.0 | nM | 4.76 |
| CHEMBL1766682 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL1766691 | — | IC50 | > | 10000.0 | nM | - |