Assay Detail
Functional
CHEMBL1767788
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against p53 deficient human HCT116 cells expressing p53 after 72 hrs by MTT assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.09 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1610049 | — | — | 1 | 5.33 |
| CHEMBL1766683 | — | — | 1 | 5.26 |
| CHEMBL1363219 | — | — | 1 | 5.25 |
| CHEMBL1766685 | — | — | 1 | 5.24 |
| CHEMBL1766688 | — | — | 1 | 5.16 |
| CHEMBL1462900 | — | — | 1 | 5.16 |
| CHEMBL1766693 | — | — | 1 | 5.14 |
| CHEMBL1766690 | — | — | 1 | 5.13 |
| CHEMBL1766682 | — | — | 1 | 5.06 |
| CHEMBL1621541 | — | — | 1 | 5.02 |
| CHEMBL1766695 | — | — | 1 | 5.00 |
| CHEMBL1766689 | — | — | 1 | 4.98 |
| CHEMBL1766681 | — | — | 1 | 4.96 |
| CHEMBL1766686 | — | — | 1 | 4.89 |
| CHEMBL1766692 | — | — | 1 | 4.79 |
| CHEMBL1766684 | — | — | 1 | - |
| CHEMBL1766687 | — | — | 1 | - |
| CHEMBL1766691 | — | — | 1 | - |
| CHEMBL1766694 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1610049 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1766683 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1363219 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL1766685 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL1766688 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1462900 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1766693 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL1766690 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1766682 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL1621541 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL1766695 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL1766689 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL1766681 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL1766686 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL1766692 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL1766684 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1766687 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1766691 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL1766694 | — | IC50 | > | 20000.0 | nM | - |