Assay Detail
Binding
CHEMBL1767809
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Inhibition of human URAT1 expressed in human MDCK cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDCK |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Developing potent human uric acid transporter 1 (hURAT1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.08 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | 4.0 | 1 | 7.46 |
| CHEMBL1767079 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388590 | BENZBROMARONE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL1767079 | — | IC50 | = | 200.0 | nM | 6.70 |