Assay Detail
Binding
CHEMBL1767946
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Inhibition of PTP1B
23
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Using small molecules to target protein phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.89 | 7.70 |
| Ki | 3 | 7.24 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL326115 | — | — | 1 | 8.62 |
| CHEMBL1765346 | — | — | 1 | 7.70 |
| CHEMBL1765345 | — | — | 1 | 7.58 |
| CHEMBL1765347 | — | — | 1 | 7.40 |
| CHEMBL601290 | — | — | 1 | 7.10 |
| CHEMBL259628 | — | — | 1 | 6.92 |
| CHEMBL591978 | — | — | 1 | 6.89 |
| CHEMBL592245 | — | — | 1 | 6.85 |
| CHEMBL1765350 | — | — | 1 | 6.66 |
| CHEMBL1765349 | — | — | 1 | 6.66 |
| CHEMBL508583 | TRODUSQUEMINE | 2.0 | 1 | 5.89 |
| CHEMBL184041 | ERTIPROTAFIB | 2.0 | 1 | 5.80 |
| CHEMBL193233 | — | — | 1 | 5.60 |
| CHEMBL1765360 | — | — | 1 | 5.52 |
| CHEMBL1765359 | — | — | 1 | 5.48 |
| CHEMBL1232829 | — | — | 1 | 5.10 |
| CHEMBL18927 | — | — | 1 | 4.70 |
| CHEMBL1234135 | — | — | 1 | 4.70 |
| CHEMBL1765348 | — | — | 1 | 4.70 |
| CHEMBL364328 | — | — | 1 | 4.70 |
| CHEMBL19332 | — | — | 1 | 4.70 |
| CHEMBL145280 | — | — | 1 | 4.40 |
| CHEMBL190801 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL326115 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL1765346 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL1765345 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL1765347 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL601290 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL259628 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL591978 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL592245 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1765350 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1765349 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL508583 | TRODUSQUEMINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL184041 | ERTIPROTAFIB | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL193233 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1765360 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL1765359 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL1232829 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL18927 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1234135 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL1765348 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL364328 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL19332 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL145280 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL190801 | — | IC50 | = | 1600000.0 | nM | - |