Assay Detail
Binding
CHEMBL1768070
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Mycobacterium tuberculosis ptpB
12
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium tuberculosis |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphotyrosine-protein phosphatase PTPB (CHEMBL4540) ↗| Type | SINGLE PROTEIN |
| Organism | Mycobacterium tuberculosis |
Publication
Using small molecules to target protein phosphatases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.06 | 6.66 |
| Ki | 2 | 6.71 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765363 | — | — | 2 | 6.82 |
| CHEMBL1765362 | — | — | 1 | 6.66 |
| CHEMBL1765366 | — | — | 2 | 6.60 |
| CHEMBL368885 | — | — | 1 | 6.44 |
| CHEMBL178884 | — | — | 1 | 6.37 |
| CHEMBL1230587 | — | — | 1 | 6.36 |
| CHEMBL1765361 | — | — | 1 | 5.95 |
| CHEMBL1765367 | — | — | 1 | 5.90 |
| CHEMBL1765364 | — | — | 1 | 5.16 |
| CHEMBL1765365 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765363 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL1765362 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL1765366 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL1765366 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL368885 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL178884 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL1230587 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1765363 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL1765361 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL1765367 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL1765364 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL1765365 | — | IC50 | = | 9600.0 | nM | 5.02 |