Assay Detail
Functional
CHEMBL1768194
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Agonist activity at human NTS2 receptor expressed in HEK293 cells assessed as inhibition of constitutive activity on MAPK-mediated luciferase activity
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.35 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | — | 1 | 6.96 |
| CHEMBL1766825 | — | — | 1 | 6.32 |
| CHEMBL1766946 | — | — | 1 | 6.23 |
| CHEMBL1766945 | — | — | 1 | 6.16 |
| CHEMBL1766944 | — | — | 1 | 6.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407196 | NEUROTENSIN | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1766825 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL1766946 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1766945 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL1766944 | — | EC50 | = | 840.0 | nM | 6.08 |