Assay Detail
Binding
CHEMBL1768524
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 6.25 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492634 | — | — | 1 | 6.32 |
| CHEMBL226838 | — | — | 1 | 6.23 |
| CHEMBL1766456 | — | — | 1 | 6.20 |
| CHEMBL1766441 | — | — | 1 | - |
| CHEMBL1766442 | — | — | 1 | - |
| CHEMBL1766443 | — | — | 1 | - |
| CHEMBL1766444 | — | — | 1 | - |
| CHEMBL1766445 | — | — | 1 | - |
| CHEMBL1766446 | — | — | 1 | - |
| CHEMBL1766447 | — | — | 1 | - |
| CHEMBL1766448 | — | — | 1 | - |
| CHEMBL1766440 | — | — | 1 | - |
| CHEMBL1766450 | — | — | 1 | - |
| CHEMBL1766451 | — | — | 1 | - |
| CHEMBL1766452 | — | — | 1 | - |
| CHEMBL1766453 | — | — | 1 | - |
| CHEMBL1766454 | — | — | 1 | - |
| CHEMBL1766455 | — | — | 1 | - |
| CHEMBL1766449 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492634 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL226838 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL1766456 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1766441 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766442 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766443 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766444 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766445 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766446 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766447 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766448 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766440 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766450 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766451 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766452 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766453 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766454 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766455 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL1766449 | — | IC50 | > | 1000.0 | nM | - |