Assay Detail
Functional
CHEMBL1768674
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against mouse NIH/3T3 cells expressing TPR-Met after 72 hrs
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and c-Met kinase inhibition of 3,5-disubstituted and 3,5,7-trisubstituted quinolines: identification of 3-(4-acetylpiperazin-1-yl)-5-(3-nitrobenzylamino)-7- (trifluoromethyl)quinoline as a novel anticancer agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.52 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1766539 | — | — | 1 | 5.85 |
| CHEMBL261641 | — | — | 1 | 5.70 |
| CHEMBL1766542 | — | — | 1 | 5.66 |
| CHEMBL1766529 | — | — | 1 | 5.58 |
| CHEMBL1766530 | — | — | 1 | 5.40 |
| CHEMBL1766543 | — | — | 1 | 5.23 |
| CHEMBL1766544 | — | — | 1 | 5.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1766539 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL261641 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1766542 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1766529 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL1766530 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1766543 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL1766544 | — | IC50 | = | 6500.0 | nM | 5.19 |