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Target Snapshot

CHEMBL614822 Target Snapshot

NIH3T3 · CELL-LINE · Mus musculus

Back to Search Search this target Browse approvals Evidence Card
4,375Compounds
1,133Assays
32Approved Drugs
3,265.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NIH3T3 as ChEMBL target CHEMBL614822. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NIH3T3
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL614822
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NIH3T3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNIH3T3
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNIH3T3
UniProt AccessionN/A

NIH3T3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NIH3T3.

Review nameNIH3T3
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

32
Approved
13
Phase III
8
Phase II
5
Phase I
Assay Mix

Activity Type Distribution

IC502,624.0
KI20.0
EC50621.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL332230 10.0 EC50 0.1 Preclinical
CHEMBL39805 9.4 EC50 0.4 Preclinical
CHEMBL216420 9.34 IC50 0.46 Preclinical
CHEMBL429542 9.33 IC50 0.47 Preclinical
CHEMBL578497 9.3 IC50 0.5 Preclinical
CHEMBL598922 9.3 IC50 0.5 Preclinical
CHEMBL599324 9.3 IC50 0.5 Preclinical
CHEMBL601202 9.3 IC50 0.5 Preclinical
CHEMBL601408 9.3 IC50 0.5 Preclinical
CHEMBL605371 9.3 IC50 0.5 Preclinical
Distribution

pChEMBL Value Distribution

368
5.0
237
5.5
170
6.0
87
6.5
109
7.0
73
7.5
38
8.0
27
8.5
16
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LONAFARNIB
CHEMBL298734
Approved 2020
Properties Compare Identifier
GEFITINIB
CHEMBL939
Approved 2003
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DAUNORUBICIN
CHEMBL178
Approved 1979
Properties Compare Identifier
CLOTRIMAZOLE
CHEMBL104
Approved 1975
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
DOXORUBICIN HYDROCHLORIDE
CHEMBL359744
Approved 1974
Properties Compare Identifier
FLOXURIDINE
CHEMBL917
Approved 1970
Properties Compare Identifier
VINBLASTINE
CHEMBL159
Approved 1965
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

1,135
Total Assays
1,020
Tested Compounds
4
Assay Types
Functional — 655 assays, 1,020 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 590 1,015 5.7
organism-based format 65 5 8.1
ADME — 359 assays, 867 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 359 867 5.1
Toxicity — 112 assays, 121 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 112 121 5.7
Unassigned — 9 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine