Assay Detail
Functional
CHEMBL1768789
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Antiproliferative activity against human HEL 92.1.7 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEL |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.79 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1765738 | — | — | 1 | 4.92 |
| CHEMBL1765744 | — | — | 1 | 4.80 |
| CHEMBL1614777 | — | — | 1 | 4.75 |
| CHEMBL1765750 | — | — | 1 | 4.75 |
| CHEMBL1765743 | — | — | 1 | 4.72 |
| CHEMBL1765740 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1765738 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1765744 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1614777 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1765750 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1765743 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL1765740 | — | IC50 | > | 30000.0 | nM | - |